Figures & data
Table 1. Organ weights at terminal necropsy and body weights from Day 1 to Day 6.
Table 2. aGravimetric concentrations, nickel concentrations and aerosol particle size.
Figure 1. Individual IgM antibody-forming cell responses to SRBC in female CD-1 mice following 24-hr whole-body inhalation exposure to nickel chloride hexahydrate. (A) Inter-leaved scatter with bars of individual spleen cell numbers in vehicle control, nominal nickel chloride hexahydrate treatment groups, and positive control (CP). (B) Inter-leaved scatter with bars of individual Total Spleen Activity [IgM AFC/spleen (103)] values. (C) Inter-leaved scatter with bars of individual Specific Activity [IgM AFC/spleen cells (106)] responses to SRBC on Day 4 after exposure. Scatter plots: biological variability of the responses in outbred mice, with low and high responders even in controls. N = 10 mice/group. *p < 0.05; **p < 0.01 vs. control (Group 1).
![Figure 1. Individual IgM antibody-forming cell responses to SRBC in female CD-1 mice following 24-hr whole-body inhalation exposure to nickel chloride hexahydrate. (A) Inter-leaved scatter with bars of individual spleen cell numbers in vehicle control, nominal nickel chloride hexahydrate treatment groups, and positive control (CP). (B) Inter-leaved scatter with bars of individual Total Spleen Activity [IgM AFC/spleen (103)] values. (C) Inter-leaved scatter with bars of individual Specific Activity [IgM AFC/spleen cells (106)] responses to SRBC on Day 4 after exposure. Scatter plots: biological variability of the responses in outbred mice, with low and high responders even in controls. N = 10 mice/group. *p < 0.05; **p < 0.01 vs. control (Group 1).](/cms/asset/4150f359-1121-41d7-a842-d6520ee29a18/iimt_a_1984618_f0001_b.jpg)
Table 3. Summary of immunotoxicity findings in mice with 24-hr exposure to NiCl2·6H2O.