Preliminary Psychometric Evaluation of the Hamilton Depression Rating Scale in Methamphetamine Dependence

Figures & data

Table 1. Subject characteristics.

	Major Depressive Disorder	No Major Depressive Disorder	Unknown Depression Status
Participant demographics
Age, years (mean, SD)	36.2 (9.1)	30.1 (6.3)	35.2 (6.6)
Sex (%)
Female	87.9	54.4	87
Race (%)
American Indian	4 (6.9)	1 (4.8)	—
White	51 (87.9)	18 (85.7)	22 (95.7)
Black or African American	—	1 (4.8)	—
More than two races	2 (3.4)	—	1 (4.3)
Participant declined	1 (4.8)	1 (4.8)	—
Ethnicity (%)
Hispanic or Latino	3 (5.2)	3 (14.3)	5 (21.7)
Not Hispanic or Latino	55 (94.8)	18 (85.7)	18 (78.3)
Years of education (mean, SD)	12.9 (2.0)	12.7 (1.6)	12.3 (1.8)
Onset of methamphetamine use, age in years (mean, SD)	21.2 (7.5)	20.6 (5.4)	21.6 (8.2)
Methamphetamine dependence current (%)	84.5	95.2	87.5
Methamphetamine dependence lifetime (%)	98.3	100	30.4
Methamphetamine abuse current (%)	—	—	4.3
Methamphetamine abuse lifetime (%)	1.7	—	4.3
17-item Hamilton Depression Rating Scale score (mean, SD)	17.5 (4.3)	9.4 (3.9)	15.3 (5.9)

Note. SD = standard deviation.

Table 2. Estimated intercorrelations between items.

	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	Total
1	1.00
2	0.27	1.00
3	0.27	0.14	1.00
4	0.00	0.02	0.16	1.00
5	0.08	0.24	0.13	0.29	1.00
6	0.01	0.03	0.23	0.05	0.35	1.00
7	0.38	0.22	0.32	0.01	0.14	0.01	1.00
8	−0.03	−0.11	−0.06	−0.06	0.01	0.03	0.28	1.0
9	0.06	−0.03	−0.22	−0.11	0.06	−0.16	−0.12	0.18	1.00
10	0.23	0.36	0.13	0.00	0.02	0.12	0.12	0.14	0.12	1.00
11	0.26	0.27	0.06	0.03	0.26	0.17	0.00	−0.19	0.10	0.39	1.00
12	0.14	0.07	−0.08	0.11	0.06	0.14	0.08	−0.11	−0.10	0.25	0.43	1.00
13	0.26	0.33	0.03	0.05	0.21	−0.06	0.32	0.09	0.06	0.35	0.24	0.17	1.00
14	−0.09	−0.09	−0.01	−0.06	−0.08	−0.02	0.15	0.10	0.05	0.05	0.02	0.04	0.15	1.00
15	0.29	0.08	0.16	0.24	0.13	0.03	0.17	−0.01	0.06	0.21	0.16	−0.04	0.34	0.12	1.00
16	−0.06	−0.05	0.00	−0.07	0.06	0.12	−0.05	0.31	−0.04	0.11	−0.01	0.21	−0.08	−0.04	−0.12	1.00
17	−0.08	−0.07	−0.17	−0.08	−0.08	−0.17	0.02	0.16	0.29	−0.09	−0.16	−0.06	−0.15	−0.23	−0.19	0.04	1.00
Total	0.53	0.47	0.36	0.28	0.48	0.29	0.51	0.16	0.16	0.56	0.55	0.38	0.57	0.18	0.49	0.12	−0.10	1.00

Note. Intercorrelations greater than 0.20 are in bold.

Table 3. Sample means and two-sample t-tests for Hamilton Depression Rating Scale items by Major Depressive Disorder status.

	Major Depressive Disorder		No Major Depressive Disorder
Item	Mean	SD	Mean	SD	Difference	t value	p value	CI
Item 1	1.84	0.91	0.76	1.04	1.08	4.48	<.01	[0.60, 1.56]
Item 2	1.74	0.79	1.05	0.97	0.69	2.94	.01	[0.27, 1.12]
Item 3	0.47	0.73	0.00	0.00	0.47	2.80	<.01	[0.15, 0.78]
Item 4	0.91	0.94	0.67	0.86	0.25	1.10	.28	[−0.22, 0.71]
Item 5	0.91	0.88	0.62	0.74	0.29	1.48	.15	[−0.14, 0.73]
Item 6	0.57	0.82	0.24	0.62	0.33	1.91	.06	[−0.06, 0.72]
Item 7	1.91	1.00	1.05	1.36	0.87	2.67	.01	[0.31, 1.43]
Item 8	0.05	0.22	0.10	0.30	0.04	0.6	.55	(−0.17, 0.08)
Item 9	0.91	0.76	1.10	1.04	0.18	0.73	.47	[−0.61, 0.24]
Item 10	2.14	0.89	1.24	1.00	0.90	3.65	<.01	[0.44, 1.36]
Item 11	1.40	1.09	0.52	0.98	0.87	3.39	<.01	[0.33, 1.41]
Item 12	0.60	0.79	0.29	0.56	0.32	1.98	.05	[0.06, 0.69]
Item 13	1.60	0.64	0.24	0.54	1.37	9.41	<.01	[1.05, 1.68]
Item 14	0.79	0.85	0.67	0.73	0.13	0.65	.52	[−0.29, 0.54]
Item 15	1.29	1.17	0.29	0.56	1.01	5.13	<.01	[0.48, 1.54]
Item 16	0.21	0.59	0.24	0.62	−0.03	0.20	.84	[−0.33, 0.27]
Item 17	0.10	0.36	0.38	0.80	−0.28	1.53	.14	[−0.54, 0.02]
Total score	17.48	4.26	9.43	3.92	8.05	7.88	<.01	[5.94, 10.17]

Note. Items in bold indicate nonsignificant finding at the 5% significance level.

SD = standard deviation; CI = confidence interval.

Table 4. Rotated factor loadings.

	Factor 1	Factor 2	Factor 3	Factor 4	Factor 5	Factor 6
Item 1	0.71	0.19	−0.02	−0.02	−0.12	−0.06
Item 2	0.55	0.36	0.08	0.03	−0.17	−0.18
Item 3	0.50	−0.14	0.23	−0.52	0.03	−0.04
Item 4	−0.01	−0.08	0.68	−0.06	−0.14	0.07
Item 5	0.12	0.17	0.79	0.05	0.11	−0.10
Item 6	−0.08	0.25	0.47	−0.40	0.30	−0.06
Item 7	0.74	−0.14	−0.01	−0.13	0.27	0.15
Item 8	0.16	−0.22	0.00	0.27	0.78	0.16
Item 9	−0.02	0.03	0.06	0.81	0.05	0.00
Item 10	0.38	0.57	−0.02	0.15	0.16	0.15
Item 11	0.14	0.77	0.18	0.06	−0.17	0.04
Item 12	−0.03	0.73	−0.03	−0.13	0.13	0.02
Item 13	0.50	0.29	0.11	0.24	−0.03	0.41
Item 14	−0.07	0.01	−0.14	−0.02	0.12	0.80
Item 15	0.36	−0.01	0.37	0.14	−0.20	0.47
Item 16	−0.14	0.24	−0.02	−0.11	0.71	−0.13
Item 17	0.03	−0.21	−0.12	0.50	0.20	−0.53
Eigenvalue	2.97	1.72	1.59	1.50	1.34	1.24

Note. Bold values indicate items with factor loadings greater than 0.4 in absolute value.