Antibacterial, Spectral, and Thermal Aspects of Some [1,2,4-triazolo] [3,4-b][1,3,4]thiadiazine Based Heterochelates

Abstract

New ligands 5-((4-(3-(pyridine-4-yl)-7H-[1,2,4]triazolo[3,4-b] [1, 3,4]thiadiazine-6-yl)phenylamino)methyl)quinolin-8-ol (L₁) and 5-((3-(pyridine-4-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-6- ylamino)methyl)quinolin-8-ol (L₂) have been synthesized. The obtained ligands were characterized by ¹H NMR, ¹³C NMR, and IR spectroscopic techniques, and reacted with transition metal salts to afford metal containing heterochelates. The structures of the synthesized heterochelates were characterized using elemental analyses, infrared spectra, electronic spectra, magnetic measurements, FAB mass spectrum, and thermo gravimetric analyses. The kinetic parameters, such as order of reaction (n) and the energy of activation (Ea), are reported using the Freeman–Carroll method. Ligands and heterochelates were also screened for their in vitro antibacterial activity.

Keywords:

• 8-hyrdroxy quinoline
• in vitro antibacterial activity
• spectroscopy studies
• thermal studies
• thiadiazine

Acknowledgments

The authors express gratitude to Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, India for providing laboratory facilities. Analytical facilities provided by the SAIF, Central Drug Research Institute, Lucknow, India. One of the authors, Kaushal K. Oza, is thankful to UGC New Delhi for providing scholarship.