Synthesis, Structures, and Antimicrobial Activity of Zinc and Copper Complexes Derived From N-isopropyl-N′-(1-pyridin-2-ylethylidene)ethane-1,2-diamine

Abstract

The Schiff base N-isopropyl-N′-(1-pyridin-2-ylethylidene) ethane-1,2-diamine (L) derived from 2-acetylpyridine and N-isopropylethane-1,2-diamine, and its mononuclear zinc(II) and polymeric copper(II) complexes, [ZnL(NCS)₂] and [CuL(μ ₂-NCS)] _n ·nBF₄, have been prepared and characterized by elemental analyses, IR, and single-crystal X-ray crystallographic determination. The Schiff base coordinates to the metal atoms through the three N atoms. The Zn atom in [ZnL(NCS)₂] adopts a trigonal-bipyramidal coordination, and the Cu atom in [CuL(μ ₂-NCS)] _n ·nBF₄ adopts a square-pyramidal coordination. The effect of the complexes on the antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans were studied.

Keywords:

• synthesis
• crystal structure
• antimicrobial
• Schiff base
• zinc complex

Acknowledgments

The authors thank the top-class foundation and the Applied Chemistry Key Laboratory foundation of the Pingdingshan University.