Synthesis of Fe₂O₃ Nanoparticles Via Various Methods and Coating With Silica for Drug Immobilization

Abstract

Synthesis of Fe₂O₃ nanoparticles was investigated using precipitation and thermal decomposition methods. Ammonia and urea, as alkali materials, were used in precipitation method. For comparison, Fe₂O₃ nanoparticles was prepared from thermal decomposition method in 2-hydroxy ethyl ammonium formate and 1,2-propan diol as solvent. The SEM images show that thermal decomposition method in presence of surfactant gives the best result for Fe₂O₃ nanoparticles. These particles were coated with silica and then the citallopram hydrobromid was immobilized on coated nanoparticle surface. TEM images show the silica layer on Fe₂O₃ nanoparticles and immobilization of the drug was proved from the FT-IR spectrum.

Keywords:

• nanoparticles
• SEM
• synthesis
• TEM

Acknowledgments

Financial support from Islamic Azad University, Ardabil Branch is gratefully acknowledged.