Synthesis, Thermal, and Biological Studies of Newly Synthesized Cu(II) Complexes With Ciprofloxacin Based on Bromo-Coumarins Derivatives

Abstract

The authors describe synthesis, characterization, and biological evaluation of Cu(II) complexes. Characterization of ligands has been carried out by elemental analysis, melting point, mass spectra, (¹H & ¹³C) NMR, and FT-IR, while structure of metal complexes was confirmed by electronic spectra and FAB-mass spectral studies. Spectral studies confirm ligands is mono functional bidentate and octahedral environment around metal ions. Thermal behavior of Cu(II) complexes were investigated by means of TGA and magnetic measurements. The kinetic parameters are reported using the Freeman-Carroll method. Complexes were found significant potent antimicrobial and antioxidant activities compared to parent ligands employed for complexation.

Supplemental materials are available for this article. Go to the publisher's online edition of Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry to view the supplemental file.

Keywords:

• antimicrobial
• antioxidant
• ciprofloxacin

Acknowledgments

The authors are grateful to the Principal and management of V. P. & R. P. T. P. Science College, Vallabh Vidyanagar, for providing infrastructures and obligatory facilities for research. They are thankful to the Director, SICART, Vallabh Vidyanagar, for analytical facilities. The authors are also grateful to the Director, SAIF-RSIC, Panjab University, Chandigarh, for NMR analysis. They articulate their appreciation to IIT-Bombay for the TG and DTG scan analysis facility.