Abstract
The new ruthenium(II) ferrocenyl heterocyclic thiosemicarbazone complexes of the type [RuCl(CO)(EPh3)L] (where E = P/As; L = Monobasic tridendate thiosemicarbazone ligands) have been synthesized and structural features were determined by analytical and spectral techniques. Binding of these complexes with CT-DNA by absorption spectroscopy indicate that the ruthenium(II) complexes form adducts with DNA and has intrinsic binding constant in the range of 1.0–3.6 × 104 M−1. The complexes exhibit a remarkable DNA cleavage activity with pBR322 DNA in the presence of H2O2 and the efficiency was found to be dose dependent. In vitro cytotoxicity study of the complexes showed significant cytotoxicity against HeLa tumor line.
Acknowledgments
The authors sincerely thank Council of Scientific and Industrial Research (CSIR), New Delhi, [Scheme. No. 01(2308)/09/EMR-II] for financial support.