Preparation of magnetic molecularly imprinted nanoparticles for selective separation and determination of prednisolone drug

ABSTRACT

In this study the authors present a general method to prepare magnetic molecularly imprinted polymers for prednisolone. The resulting Fe₃O₄@MIPs nanoparticles possessed a highly improved imprinting effect, fast adsorption kinetics, and high adsorption capacity and can be applied to extract prednisolone in plasma samples. In this case, we were synthesized prednisolone magnetic nanoparticles coated with imprinted polymer by using a semicovalent imprinting method. Where the template was linked to the silica coating on the iron oxide core via a thermally reversible bond.

KEYWORDS:

• Imprinted nanoparticles
• magentic molecularly
• selective separation