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Autophagic Puncta

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

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Pages 963-964 | Received 06 Apr 2015, Accepted 13 Apr 2015, Published online: 15 Jun 2015

Figures & data

Figure 1. HK2 detects glucose depletion to bind and inhibit MTORC1, enhancing autophagy. In the presence of glucose, the binding is inhibited by glucose 6-phosphate (G6P) generated by HK2 catalytic activity. Glc, glucose.

Figure 1. HK2 detects glucose depletion to bind and inhibit MTORC1, enhancing autophagy. In the presence of glucose, the binding is inhibited by glucose 6-phosphate (G6P) generated by HK2 catalytic activity. Glc, glucose.

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