Figure 1. Regulation of TFEB activity by intracellular calcium signaling. Extra- and intracellular stimuli induce elevation of cytoplasmic Ca2+ levels by releasing Ca2+ from the lysosome. Elevated cytosol Ca2+ can suppress MTORC1-dependent pathways, and (or) activate calcineurin-dependent pathways, subsequently inducing dephosphorylation of TFEB, and resulting in the activation of autophagy.
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