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Autophagy Volume 14, 2018 - Issue 1
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Autophagic Puncta

HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease

Yuhua FuState Key Laboratory of Medical Neurobiology, Huashan Hospital, School of Life Sciences, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, ChinaView further author information
,
Xiaoli SunState Key Laboratory of Medical Neurobiology, Huashan Hospital, School of Life Sciences, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, ChinaView further author information
&
Boxun LuState Key Laboratory of Medical Neurobiology, Huashan Hospital, School of Life Sciences, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1675-9340View further author information
ORCID Icon
Pages 169-170 | Received 09 Oct 2017, Accepted 11 Oct 2017, Published online: 29 Jan 2018

Figures & data

Figure 1. HIPK3 regulates the mHTT level via autophagy. mHTT upregulates HIPK3 expression and inhibits autophagy via DAXX. The decreased autophagy further increases the mHTT level and enhances HIPK3 expression, forming a positive feedback loop. This may contribute to mHTT accumulation and disease progression.

Figure 1. HIPK3 regulates the mHTT level via autophagy. mHTT upregulates HIPK3 expression and inhibits autophagy via DAXX. The decreased autophagy further increases the mHTT level and enhances HIPK3 expression, forming a positive feedback loop. This may contribute to mHTT accumulation and disease progression.

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