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Figure 1. Effects of clockophagy on ferroptosis. Clockophagy promotes ferroptosis through the autophagic degradation of ARNTL via the cargo reseptor SQSTM1 and core autophagy components ATG5 and ATG7. The degradation of ARNTL can promote EGLN2 transcription, which leads to the proteasomal degradation of HIF1A. Consequently, the downregulation of HIF1A limits lipid storage and finally increases lipid peroxidation during ferroptosis.
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