Figures & data
Figure 1. Anabolism and catabolism are upregulated in activated B cells in a coordinated manner. MTOR integrates growth and nutrient signals to promote translation and cellular growth. Despite the high MTOR activity, autophagy is also upregulated in activated B cells via MTOR-independent signaling pathways. High autophagic flux relies on efficient protein synthesis. Specifically, spermidine sustains optimal translation via hypusinating EIF5A, which is required for maintaining high TFEB protein levels. Autophagy may in turn provide nutrients and degrade damaged organelles to assist the high growth rate and antibody production of activated B cells.
