Figures & data
Figure 1. Role of Atg8a and seq in the negative regulation of autophagy. In nutrient-rich conditions, the transcription factor seq interacts with Atg8a in a LIR motif-dependent manner, and localizes at the promoter regions of autophagy-related (Atg) genes to repress their expression. In such conditions, Atg8a acetylation is maintained by its interaction with an acetyltransferase complex via YL-1. When nutrients are scarce, Atg8a is deacetylated by Sirt2, resulting in a stronger binding to seq, which can be lifted from the autophagy gene promoters, leading to their transcriptional activation.
