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Autophagy Volume 17, 2021 - Issue 8
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Autophagic Punctum

The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor

Thaddaeus Mutugi NthigaAutophagy Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, Tromsø, NorwayORCID Iconhttps://orcid.org/0000-0002-6537-3903View further author information
ORCID Icon,
Birendra Kumar ShresthaAutophagy Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, Tromsø, NorwayView further author information
,
Trond LamarkAutophagy Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, Tromsø, NorwayORCID Iconhttps://orcid.org/0000-0001-6338-3342View further author information
ORCID Icon &
Terje JohansenAutophagy Research Group, Department of Medical Biology, University of Tromsø – The Arctic University of Norway, Tromsø, NorwayCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1451-9578View further author information
ORCID Icon
Pages 2051-2052 | Received 01 Jun 2021, Accepted 04 Jun 2021, Published online: 24 Jun 2021

Figures & data

Figure 1. Role of CALCOCO1 during Golgiphagy. Upon nutrient stress, CALCOCO1 mediates the degradation of Golgi fragments through interaction with the Golgi-localized transmembrane palmitoyl transferase ZDHHC17. CALCOCO1 binds to the ankyrin repeats of ZDHHC17 (or ZDHHC13) via its zDABM motif and recruits the autophagy machinery via LIR-LDS- and UIR-UDS-mediated interactions with Atg8-family proteins (ATG8) to initiate phagophore formation. The Golgi fragments are subsequently sequestrated within autophagosomes and degraded when the autophagosomes fuse with lysosomes. The dual ability of CALCOCO1 to also degrade ER via FFAT-motif interactions with ER-localized VAP proteins is also indicated

Figure 1. Role of CALCOCO1 during Golgiphagy. Upon nutrient stress, CALCOCO1 mediates the degradation of Golgi fragments through interaction with the Golgi-localized transmembrane palmitoyl transferase ZDHHC17. CALCOCO1 binds to the ankyrin repeats of ZDHHC17 (or ZDHHC13) via its zDABM motif and recruits the autophagy machinery via LIR-LDS- and UIR-UDS-mediated interactions with Atg8-family proteins (ATG8) to initiate phagophore formation. The Golgi fragments are subsequently sequestrated within autophagosomes and degraded when the autophagosomes fuse with lysosomes. The dual ability of CALCOCO1 to also degrade ER via FFAT-motif interactions with ER-localized VAP proteins is also indicated

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