https://orcid.org/0000-0002-7923-578XView further author information & https://orcid.org/0000-0001-5563-9096View further author informationFigure 1. Proposed model of BECN1-regulated adiponectin secretion in adipose tissue. When released from BCL2 inhibition, BECN1 is translocated from the ER-Golgi-mitochondrial pools to ADIPOQ vesicles. There it interacts with the exocyst EXOC3/SEC6-EXOC4/SEC8 subcomplex and promotes adiponectin secretion, leading to improvement of systemic insulin sensitivity by activating the AMPK signaling pathway in metabolic organs
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