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Autophagy Volume 17, 2021 - Issue 12
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Autophagic Punctum

A conserved Vac8/ARMC3-PtdIns3K-CI cascade regulates autophagy initiation and functions in spermiogenesis by promoting ribophagy

Yuqing Leia Department of Pathology, West China Second University Hospital, State Key Laboratory of Biotherapy, and Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University, Chengdu, ChinaView further author information
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Xueguang Zhangb Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (Scu-cuhk), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaView further author information
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Qingjia Xuc Department of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaView further author information
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Shiyan Liuc Department of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaView further author information
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Chunxia Lic Department of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaView further author information
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Hui Jiangd Department of Urology, Peking University Third Hospital, Beijing, China;e Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing, ChinaView further author information
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Haocheng Lind Department of Urology, Peking University Third Hospital, Beijing, China;e Department of Reproductive Medicine Center, Peking University Third Hospital, Beijing, ChinaView further author information
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Eryan Kongf Institute of Psychiatry and Neuroscience, Xinxiang Medical University, Xinxiang, ChinaView further author information
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Jiaming Liug Department of Urology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaView further author information
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Shiqian Qig Department of Urology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaORCID Iconhttps://orcid.org/0000-0002-7589-8877View further author information
ORCID Icon,
Huihui Lia Department of Pathology, West China Second University Hospital, State Key Laboratory of Biotherapy, and Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University, Chengdu, ChinaView further author information
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Wenming Xub Department of Obstetrics/Gynecology, Joint Laboratory of Reproductive Medicine (Scu-cuhk), Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaView further author information
&
Kefeng Lua Department of Pathology, West China Second University Hospital, State Key Laboratory of Biotherapy, and Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, Sichuan University, Chengdu, China;c Department of Neurology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaCorrespondence[email protected] [email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-8200-9380View further author information
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Pages 4512-4514 | Received 05 Sep 2021, Accepted 30 Sep 2021, Published online: 27 Oct 2021

Figures & data

Figure 1. Illustration of Vac8 functions in autophagy and ARMC3-mediated ribophagy in spermiogenesis. (A) The N-terminal cysteines of Vac8 are palmitoylated, which enables Vac8 localization to the vacuole membrane. Vac8 then recruits the Atg1 complex and the PtdIns3K-CI complex to the vacuole membrane, which leads to the generation of PtdIns3P and initiates autophagosome formation. (B) During spermatogenesis, ARMC3 is specifically expressed and promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility

Figure 1. Illustration of Vac8 functions in autophagy and ARMC3-mediated ribophagy in spermiogenesis. (A) The N-terminal cysteines of Vac8 are palmitoylated, which enables Vac8 localization to the vacuole membrane. Vac8 then recruits the Atg1 complex and the PtdIns3K-CI complex to the vacuole membrane, which leads to the generation of PtdIns3P and initiates autophagosome formation. (B) During spermatogenesis, ARMC3 is specifically expressed and promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility

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