https://orcid.org/0000-0001-9402-9581
Figures & data
Figure 1. A summary of the various aspects of PDGFRA regulation by autophagy. Following receptor endocytosis upon binding to its ligand PDGFA, PDGFRA is trafficked to late endosomes marked by RAB7 where signaling activity can persist. In the absence of autophagy, receptor trafficking to late endosomes is disrupted leading to reduced signaling despite enhanced PDGFRA levels due to inhibited lysosomal degradation. In the long term, disrupted PDGFRA signaling in autophagy-inhibited cells leads to a transcriptional downregulation of PDGFRA resulting in reduced cellular availability of this receptor.
