Toxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine

Figures & data

Figure 1. Plasma-concentration versus time curve of ibogaine and noribogaine with important clinical interventions and observations.

Table 1. Toxicokinetic parameters of ibogaine and noribogaine using two compartments.

Parameter	Ibogaine	Noribogaine
CL/F (L/h)	4.66	2.30
V1 (L)	185	47.5
V2 (L)	789	1.022
t1/2,1 (h)	26.06	12.59
t1/2,2 (h)	2285	2540
k10 (/h)	0.0079
k12 (/h)	0.0014	0.0067
k21 (/h)	0.0003	0.0003
Ratio k12/k21 (-)	4.28	21.5

CL/F: Oral clearance; V₁: Volume of distribution of the central compartment; V₂: Volume of distribution of the peripheral compartment; t_1/2,1: Half-life of the distribution phase; t_1/2,2: Half-life of the elimination phase; k₁₀: Elimination rate constant from the central compartment; k₁₂: First order rate constant describing transfer first to second compartment; k₂₁: First-order rate constant describing transfer second to first compartment.