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Clinical Toxicology Volume 61, 2023 - Issue 9
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Short Communications

Measurement of an intestinal biomarker during poisonings from select toxicants and toxins

Varan Perananthana Edith Collins Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia;b Clinical Pharmacology and Toxicology Research Group, Biomedical Informatics & Digital Health, Sydney Medical School, University of Sydney, Sydney, Australia;c South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri LankaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4087-4998View further author information
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Thilini Wijerathnac South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka;d Department of Biosystems Technology, General Sir John Kotelawala Defence University, Rathmalana, Sri LankaORCID Iconhttps://orcid.org/0000-0001-7077-515XView further author information
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Fahim Mohamedc South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka;g Department of Medicine, University of Peradeniya, Peradeniya, Sri Lanka;e Sydney Pharmacy School, University of Sydney, Camperdown, NSW, Australia Pharmacology;ORCID Iconhttps://orcid.org/0000-0003-2849-7269View further author information
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Indika Bandara Gawarammanac South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka;f Department of Nephrology, Prince of Wales Hospital and Clinical School, University of New South Wales, Sydney, NSW, AustraliaView further author information
,
Andrew Dawsona Edith Collins Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia;b Clinical Pharmacology and Toxicology Research Group, Biomedical Informatics & Digital Health, Sydney Medical School, University of Sydney, Sydney, Australia;c South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri LankaORCID Iconhttps://orcid.org/0000-0002-8047-397XView further author information
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Nicholas A. Buckleya Edith Collins Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia;b Clinical Pharmacology and Toxicology Research Group, Biomedical Informatics & Digital Health, Sydney Medical School, University of Sydney, Sydney, Australia;c South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri LankaORCID Iconhttps://orcid.org/0000-0002-6326-4711View further author information
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Pages 693-696 | Received 13 Jun 2023, Accepted 25 Sep 2023, Published online: 13 Oct 2023

Figures & data

Figure 1. Median and IQR of plasma intestinal fatty acid binding protein concentrations in patients with poisoning compared to healthy controls. Statistical Significance is presented relative to control as *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. MCPA = 2-methyl-4-chlorophenoxyacetic acid.

Figure 1. Median and IQR of plasma intestinal fatty acid binding protein concentrations in patients with poisoning compared to healthy controls. Statistical Significance is presented relative to control as *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. MCPA = 2-methyl-4-chlorophenoxyacetic acid.

Figure 2. Peak plasma intestinal fatty acid binding protein concentrations in each Patient relative to time in hours (h) with values less than 75th percentile of control shaded in grey. MCPA = 2-methyl-4-chlorophenoxyacetic acid.

Figure 2. Peak plasma intestinal fatty acid binding protein concentrations in each Patient relative to time in hours (h) with values less than 75th percentile of control shaded in grey. MCPA = 2-methyl-4-chlorophenoxyacetic acid.

Data availability statement

The data that support the findings of this study are available from the corresponding author, upon reasonable request.

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