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Clinical Research

Functional vitamin B12 deficiency is a consistent feature in hospital admissions for neurological disorders due to the use of nitrous oxide

, , , , , & show all
Pages 674-679 | Received 10 Apr 2023, Accepted 18 Oct 2023, Published online: 02 Nov 2023

Figures & data

Figure 1. Impact of nitrous oxide on cobalamin metabolism. A potential mechanism of nitrous oxide toxicity is the oxidation (dashed arrows) of cobalamin’s reduced form (cobalaminI) to more oxidized forms (cobalaminII and cobalaminIII).

Figure 1. Impact of nitrous oxide on cobalamin metabolism. A potential mechanism of nitrous oxide toxicity is the oxidation (dashed arrows) of cobalamin’s reduced form (cobalaminI) to more oxidized forms (cobalaminII and cobalaminIII).

Figure 2. Box-plot representations of biological assessments. For all markers, values are represented by a point, mean by a cross, and the following values are indicated by horizontal bars from bottom to top: minimum, first quartile, median, third quartile, maximum. All these values are defined on non-aberrant values only. A value is considered as aberrant if not comprised in the [first quartile-1.5*inter-quartile range; third quartile + 1.5*inter-quartile range) interval. Horizontal dotted bars represent normal ranges of analytes.

Figure 2. Box-plot representations of biological assessments. For all markers, values are represented by a point, mean by a cross, and the following values are indicated by horizontal bars from bottom to top: minimum, first quartile, median, third quartile, maximum. All these values are defined on non-aberrant values only. A value is considered as aberrant if not comprised in the [first quartile-1.5*inter-quartile range; third quartile + 1.5*inter-quartile range) interval. Horizontal dotted bars represent normal ranges of analytes.

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