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Letter to the Editor

Letter to the Editor: “Use of urine organic acids method for the analysis of gamma-hydroxybutric acid (GHB): Importance of urease in eliminating urea interference”

, Ph.D., , M.T., , B.S., , B.A., , B.S. & , D.O.
Pages 194-196 | Published online: 07 Oct 2008

Figures & data

Fig. 1. Total ion chromatograms from a urine sample without (A) or with (B) urea treatment. Note the disappearance of urea with urease treatment. One mL of sample, with GHB concentration of 100 mg/L, was used for analysis.

Fig. 1. Total ion chromatograms from a urine sample without (A) or with (B) urea treatment. Note the disappearance of urea with urease treatment. One mL of sample, with GHB concentration of 100 mg/L, was used for analysis.

Fig. 2. Mass spectra of a urine sample without (A) or with (B) urea treatment. Sample without urease treatment shows only 43% match whereas the sample treated with urease shows 91% match to pure GHB (C).

Fig. 2. Mass spectra of a urine sample without (A) or with (B) urea treatment. Sample without urease treatment shows only 43% match whereas the sample treated with urease shows 91% match to pure GHB (C).

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