Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol

Abstract

To study the potential for delayed Type IV dermal sensitivity of a new preservative system containing 1,2-hexanediol and caprylyl glycol, 200-subject repeat insult patch tests were performed with a 15% mixture of 1,2-hexanediol and caprylyl glycol (equal parts of the 2 ingredients) in carbomer gel and a cosmetic formulation at an actual use concentration. No delayed Type IV hypersensitivity reactions were observed.

Keywords::

• Caprylyl glycol
• cosmetics
• 1,2-hexanediol
• preservatives
• repeat insult patch test
• Symdiol 68

Acknowledgments

This study was performed at TKL Research, Rochelle Park, New Jersey, USA.

Symdiol 68 was supplied by Symrise AG, Teterboro, New Jersey, USA.

Declaration of interest: Stanley Levy is a paid consultant to Revlon. Anthony Dulichan and Michael Helman are employees of Revlon. This work was supported 100% by the Revlon Research Center.