Lavandula angustifolia and combination of Lavandula angustifolia and Zataria multiflora administration attenuates prenatal lead-exposed induced learning and memory impairments in male rats

Abstract

This study evaluated the effects lavandula angustifolia (LAF) and its coadministration with Zataria multiflora (ZM) on the learning and memory of prenatal lead exposed adult male offspring rats. Pregnant rats received tap water containing 0.2% lead acetate throughout the gestation period. Two male offspring from each mother (2 months old, weighing 180–200 g) were randomly selected and were treated with saline, LAF (50, 100 & 200 mg/kg/ip/20d), ZM (50, 200 mg/kg/ip/20d) and combination of effective and ineffective doses of LAF and ZM. The results showed spatial memory deficits in antenatally lead-exposed male offspring in Morris water maze test, which ameliorates following the effective doses of LAF and ZM methanolic extract via unknown mechanism(s).

Keywords:

• Lead
• learning
• memory
• lavandula angustifolia
• Zataria multiflora
• rats

Acknowledgements

This work was supported from Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran (Grant No: KNRC-92–57).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported from Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran (Grant No: KNRC-92–57).