Protective effect of resveratrol against bisphenol A-induced reproductive toxicity in male mice

Abstract

We investigated the effect of resveratrol on reproductive toxicity induced by Bisphenol A (BPA) in male mice. Forty mice were randomly classified into five groups: Control; Bisphenol A; Bisphenol A + Resveratrol; Resveratrol and vehicle. Histological alterations, oxidative stress markers, and sperm parameters were examined. BPA caused an evident decrease in sperm motility, count, viability, and oxidative stress markers (p < 0.05). Also, the increase in malondialdehyde, tissue damage, and abnormal sperm observed in the BPA group (p < 0.05) while the treatment of resveratrol significantly increased the above disarrays (p < 0.05). Overall, we reported that resveratrol reduces negative effects caused by BPA in spermatogenesis.

Keywords:

• Bisphenol A
• oxidative stress
• resveratrol
• spermatogenesis
• mice

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This study was supported by Ardabīl University of Medical Sciences (NO: 64/102253, Ethics code: IR.ARUMS.REC.1397.115). We thanks their financial support.