Figures & data
Table 1. Population characteristics of the discovery and the replication samples from the BBC.
Figure 1. Manhattan plot for the genome-wide DNA methylation associations with early spontaneous preterm birth in 290 Black women from the Boston Birth Cohort. The dashed line represents false discovery rate = 5%.
Table 2. The top DNA methylation loci associated with early spontaneous PTB in the discovery sample and their associations with PTB subtypes in the replication sample.
Figure 2. The distribution of DNA methylation levels at the two validated sites in both the discovery and replication Black maternal samples from the Boston Birth Cohort, stratified by term vs. preterm status of the neonates. TB: term birth; sPTB: spontaneous PTB; mPTB: medically-indicated PTB. P values shown in the figure were calculated using the regression models to indicate a significant DNAm difference between mothers in each PTB subgroup and mothers with TBs.
Figure 3. The maternal-cord blood DNA methylation correlation at cg03915055 and cg06804705, and cord blood DNA methylation difference at these two sites between term and PTB neonates. TB: term birth; sPTB: spontaneous PTB; mPTB: medically-induced PTB.
Figure 4. Distributions of DNA methylation at cg03915055 and cg06804705 in mothers from the discovery sample, stratified by TB/PTB status combined with the existence of pregnancy complications. TB: term birth; sPTB: spontaneous PTB; DM/GDM: diabetes and gestational diabetes.
