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Epigenetics Volume 16, 2021 - Issue 12
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Research Paper

Epigenome-wide association study and network analysis for IgA Nephropathy from CD19+ B-cell in Chinese Population

Yifei Lina Precision Medicine Center, Department of Urology, Medical Device Regulatory Research and Evaluation Center, West China Hospital, Sichuan University, Chengdu, China;b Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAORCID Iconhttps://orcid.org/0000-0002-3184-9213View further author information
ORCID Icon,
Peiran Yinc Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaView further author information
,
Zhaozhong Zhub Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAORCID Iconhttps://orcid.org/0000-0001-5662-1541View further author information
ORCID Icon,
Yuan Pengc Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaView further author information
,
Ming Lic Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaView further author information
,
Jun Lib Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA;d Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAView further author information
,
Liming Liangb Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA;e Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAORCID Iconhttps://orcid.org/0000-0001-8261-3174View further author information
ORCID Icon &
Xueqing Yuc Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;f Department of Nephrology, Guangdong Provincial People’s Hospital, Guangzhou, ChinaCorrespondence[email protected]
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Pages 1283-1294 | Received 07 Jul 2020, Accepted 19 Nov 2020, Published online: 07 Jan 2021

Figures & data

Table 1. Demographic characteristics of 184 participants in the current study

Figure 1. Overall study design flowchart

Figure 1. Overall study design flowchart

Figure 2. Association with IgA nephropathy (a). Manhattan plot for the association with IgA nephropathy. The blue line corresponds to the threshold of epigenome-wide significance (FDR = 0.1) (b). QQ plot for the EWAS of IgA nephropathy, lambda = 1.12

Figure 2. Association with IgA nephropathy (a). Manhattan plot for the association with IgA nephropathy. The blue line corresponds to the threshold of epigenome-wide significance (FDR = 0.1) (b). QQ plot for the EWAS of IgA nephropathy, lambda = 1.12

Figure 3. (a) Heatmap of association with methylation network modules: correlation coefficient of linear mix model between module eigengene(ME) and IgAN status (IgAN), cell purity (Purity), gender and smoking status(SMK) is reported with the -log10(p-value) given inside the bracket; the degree of -log10(p-value) is illustrated with the colour legend. (b) Visualization of Magenta Module: genes in the centre are the hub genes, pairwise correlation: 0.13 to 1

Figure 3. (a) Heatmap of association with methylation network modules: correlation coefficient of linear mix model between module eigengene(ME) and IgAN status (IgAN), cell purity (Purity), gender and smoking status(SMK) is reported with the -log10(p-value) given inside the bracket; the degree of -log10(p-value) is illustrated with the colour legend. (b) Visualization of Magenta Module: genes in the centre are the hub genes, pairwise correlation: 0.13 to 1

Table 2. Significant probes (FDR<0.01) in all the significant modules

Supplemental material

Supplemental Material

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Related Research Data

Epigenome-wide Association Study and Network Analysis for IgA Nephropathy from CD19 + B-cell in Chinese Population
Source: Taylor & Francis
Epigenome-wide association study and network analysis for IgA Nephropathy from CD19+ B-cell in Chinese Population
Source: Taylor & Francis

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