https://orcid.org/0000-0002-3040-8993
Figures & data
Figure 1. Radiation-induced CVD presentation.
Figure 2. The writers of DNA methylation. DNMTs transfer a methyl group from SAM to the 5th carbon of cytosine. (A) De novo methylation process in the developing embryo by the action of DNMT3a and DNMT3b. (B) Maintenance methylation process during DNA replication to maintain the methylation profile in the daughter cells by the action of DNMT1 present at the replication fork on hemimethylated DNA. DNMT: DNA methyltransferase, SAM: S – adenosyl methionine, SAH: S-adenosyl-L-homocysteine.
Table 1. Functional analysis of CVD differentially methylated genes in literature
Figure 3. Overview of the shared outcomes of the different studies involving radiation-induced global methylation.
Figure 4. Possible mechanisms of radiation-induced DNA methylation alterations. incident ionizing radiation leads to the production of DSBs in affected cells. these DSBs as well as radiation-induced ROS can lead to NF-κB activation which in turn can lead to DNA hypermethylation and inhibition of gene expression. on the other hand, radiation-induced ROS can cause varying DNA methylation alterations by multiple mechanisms leading to either hypo- and hyper-methylation with differential regulation of gene expression. DSBs: double strand breaks, ROS: reactive oxygen species, 8-OHdG: 8-oxo-20-deoxyguanosine, 5-mC: 5-methyl cytosine, SAM: S-adenosyl methionine, DNMT: DNA methyltransferase.
