ABSTRACT
An adaptive two-stage allocation design is developed for survival responses subject to independent informative censoring. The asymptotic p value of a score test related to a hypothesis of treatment effectiveness is used to set the assignment probability of the second stage. Several characteristics of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with those of an existing competitor. Applicability of the proposed design is also illustrated through a real data.
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Acknowledgments
The authors thank the anonymous reviewer, the editor, and the associate editor for their efforts to improve the submitted version of the work.