Figures & data
Table I. Classification and criteria of major depressive disorder (DSM-IV) and depressive episode (ICD-10)
Figure 1. Stepped-care model (adapted version, original idea from NICE guideline (Citation2004).
![Figure 1. Stepped-care model (adapted version, original idea from NICE guideline (Citation2004).](/cms/asset/f312e0c5-71b6-478d-bf9e-5a4ad9b39bba/iwbp_a_222702_f0001_b.gif)
Figure 2. Phases of disease and treatment (adapted version, original from Kupfer (Citation1991)).
![Figure 2. Phases of disease and treatment (adapted version, original from Kupfer (Citation1991)).](/cms/asset/d9bad310-47b9-4e75-909a-ce42f8a83058/iwbp_a_222702_f0002_b.gif)
Table II. Antidepressants: Mode of action and commonly used doses.
Table III. Side effect profiles of antidepressants.a
Figure 3. Flow Chart: Therapeutic options in partial and nonresponders1 to initial treatment with an antidepressant in major depressive disorder. 1Partial response: 26–49% decrease in baseline symptom severity; nonresponse:≤25% decrease in baseline symptom severity. 2See . 3Caution with combining irreversible MAO inhibitors (see 2.1.8.2). 4For indications see 2.3.
![Figure 3. Flow Chart: Therapeutic options in partial and nonresponders1 to initial treatment with an antidepressant in major depressive disorder. 1Partial response: 26–49% decrease in baseline symptom severity; nonresponse:≤25% decrease in baseline symptom severity. 2See Table II. 3Caution with combining irreversible MAO inhibitors (see 2.1.8.2). 4For indications see 2.3.](/cms/asset/ca9f7a5e-3ede-41ab-850c-ea9b796adb90/iwbp_a_222702_f0003_b.gif)
Table IV. Factors associated with increased risk for recurrence in major depressive disorder.
Table V. Possible interaction of antidepressants with comedications.
Figure 4. Flow chart: therapeutic options for maintenance treatment of major depressive disorder. CBZ, carbamazepine; MT, maintenance treatment; Li, lithium. *Maintenance electroconvulsive therapy (ECT) is an option for patients responding to ECT in the acute-phase treatment or who fail two or more maintenance medication treatments. **Additional course of psychotherapy may also be considered.
![Figure 4. Flow chart: therapeutic options for maintenance treatment of major depressive disorder. CBZ, carbamazepine; MT, maintenance treatment; Li, lithium. *Maintenance electroconvulsive therapy (ECT) is an option for patients responding to ECT in the acute-phase treatment or who fail two or more maintenance medication treatments. **Additional course of psychotherapy may also be considered.](/cms/asset/14acad1c-cda0-4330-9cec-8ee67becbffb/iwbp_a_222702_f0004_b.gif)