Pharmacotherapy of adjustment disorder: A review

Figures & data

Table 1. Randomized controlled trials of the pharmacotherapy of adjustment disorder.

Authors	Intervention	Sample	AD outcome
De Leo, (1989)	Viloxazine	n = 85	All arms equal
	vs lormetazepam
	vs S-adenosylmethionine
	vs psychotherapy
	vs placebo
Ansseau et al. (1996)	Tianeptine	n = 152	All arms equal
	vs alprazolam
	vs mianserin
Volz and Kieser (1997)	Kava-kava vs placebo	n =?	Unavailable
Bourin et al. (1997)	Euphytose vs placebo	n = 91	Euphytose > Placebo
Servant et al. (1998)	Etifoxine vs buspirone	n = 170	Etifoxine > Buspirone
Razavi et al. (1999)	Trazadone vs clorazepate	n = 18	Trazodone = Clorazepate
De Wit et al. (1999)	Trazodone vs clorazepate	n = 21	Trazodone= Clorazepate
Nguyen et al. (2006)	Etifoxine vs lorazepam	n = 191	Etifoxine = Lorazepam
Woelk et al. (2007)	Ginkgo biloba vs placebo	n = 25	Unavailable
Stein (2015)	Etifoxine vs alprazolam	n = 202	Etifoxine < alprazolam (wk 4), etofoxine > alprazolam (wk 5)
Syunyakov and Neznamov (2016)	Fabomotizole vs diazepam	n = 90/150	Fabomotizole > diazepam (in whole group)

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