Two Co(II) coordination polymers: magnetic properties and application values against chronic subdural hematoma

Figures & data

Table 1. The compounds’ parameters of crystallography as well as the details of refinement

Identification code	1	2
Empirical formula	C78H76Co3N16O18	C22H20CoN4O5
Formula weight	1702.33	479.35
Temperature (K)	293.15	296.15
Crystal system	triclinic	orthorhombic
Space group	P-1	Pbcn
a (Å)	10.9732(2)	15.1529(11)
b (Å)	12.6658(3)	17.2633(14)
c (Å)	15.1425(2)	15.7425(9)
α (°)	103.369(5)	90
β (°)	108.5270(10)	90
γ (°)	95.639(3)	90
Volume (Å^3)	1907.48(7)	4118.1(5)
Z	1	8
ρcalc (g/cm^3)	1.482	1.546
μ (mm^−1)	0.727	0.877
Data/restraints/parameters	9695/3/579	5194/0/289
Goodness-of-fit on F^2	1.197	1.068
Final R indexes [I ≥ 2σ (I)]	R1 = 0.0484, ωR2 = 0.1316	R1 = 0.0445, ωR2 = 0.0981
Final R indexes [all data]	R1 = 0.0543, ωR2 = 0.1340	R1 = 0.0818, ωR2 = 0.1152
Largest diff. peak/hole/e (Å^−3)	1.13/-0.35	0.72/-0.23
CCDC	2,064,637	2,064,638

Figure 1. (a) The 1’s asymmetry unit. (b) The one-dimensional loop of [Co₂(mbib)₂] in complex 1. (c) The 1’s two-dimensional layered net. (d) The three-dimensional packing diagram of the complex 1.

Figure 2. (a) The asymmetry unit of complex 2. (b) The 2’s one-dimensional loop chain architecture. (c) The three-dimensional packing network of complex 2. (d) The interactions of π⋯π between the neighboring chains of the complex 2.

Figure 3. The PXRD models of complex 1 (a) and complex 2 (b). The TGA plot of complex 1 (c) and complex 2 (d)

Figure 4. The temperature dependence of χ_M and and χ_MT for the complex 1 between 2 and 300 K (a); The 1/χ_M plot for 1 in 25–300 K (b). The red line indicates the best fit of Curie-Weiss

Figure 5. The temperature dependence of χ_M and χ_MT for the complex 2 from 2 K to 300 K (a); The 1/χ_M plot for 2 in 25–300 K (b). The red line indicates the best fit of Curie-Weiss

Figure 6. Compound 1 decreased the pro-inflammatory cytokines content in the hematoma capsule. Intracranial subdural space was injected with the autologous venous blood every two 3-day intervals, the injection of compounds were carried out for the treatment (at 2.5 μg/kg concentration). The enzyme-linked immunosorbent assay detection kit was employed for the pro-inflammatory cytokines determination in the hematoma capsule

Figure 7. Compound enhanced the levels of anti-inflammatory cytokines in the hematoma capsule. Intracranial subdural space was injected with the autologous venous blood every two 3-day intervals, the injection of compounds were performed for the treatment (with 2.5 μg/kg concentration). In the hematoma capsule, the content of IL-10 was determined via applying the enzyme-linked immunosorbent assay detection kit

Figure 8. Both compounds 1 and 2 has no cytotoxicity on the normal human cells. The normal human cells in the logical growth phage were collected and seeded into the 96 well plates. Then, compounds 1 and 2 was added for treatment with serial different dilutions (1, 2, 4, 8, 10, 20, 40 and 80 μM). The viability of the normal human cells was determined with CCK-8 detection