The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis

Figures & data

Figure 1. Flow diagram of the study selection process.

Table 1. Characteristics of included studies.

Author	Public Year	Location	Study Year	NOS	Detection	Groupe	N	Male/Female	age, years	AA	AT	TT	HWE
													Χ^2*	P
Chang H	2010	China	2006.2–2007.12	6	ARMS-PCR	AA	54	28/26	37.74 ± 17.37	6	25	23	0.460	0.4976
						Co	51	27/24	26.9 ± 11.2	20	22	9
El Mahgoub IR	2014	Egypt	2010.9–2011.5	7	ARMS-PCR	AA	50	24/26	11.2 ± 7.135	16	21	13	4.340	0.0372
						Co	50	27/23	11.51 ± 7.25	31	13	6
Fermo E	2004	Italy	NA	5	PCR-SSP	AA	80	NA	NA	6	19	15	0.997	0.3180
						Co	363	NA	NA	116	170	77
Lee YG	2010	Korea	2000.1–2008.12	6	NA	AA	80	41/39	38(26–49)	61	15	3	1.080	0.2986
						Co	84	44/40	37(26–49)	66	17	0
Zayed RA	2015	Egypt	NA	7	PCR-PFLP	AA	40	20/20	11(2–50)	9	17	14	5.181	0.0228
						Co	40	21/19	12(2–50)	19	12	9

AA: aplastic anemia group; Co: control group; NOS: Newcastle-Ottawa Scale; N: The total number of including; ARMS-PCR: amplification refractory mutation system-polymerase chain reaction; PCR-SSP: Polymerase chain reaction-sequence-specific primer; PCR-PFLP: polymerase chain reaction-restriction fragment length polymorphism; *: likelihood-ratio Χ²; HWE: Hardy-Weinberg equilibrium tests of control group.

Figure 2. Overall meta-analyses for assessing relationship of IFN-γ polymorphisms with aplastic anemia risk.

Table 2. Results of meta-analysis.

Gene model	Sample size			Test of association			Model	Test of heterogeneity^a,b			Publication bias^c
	K	AA	Co	OR(95%CI)	Z	P		Q	P	I^2 (%)	t	P
T vs A	5	526	1174	2.1749 [1.6825; 2.8114]	5.93	<0.01	F	3.74	0.44	0	0.5748	0.6057
TA vs AA	5	195	486	2.1071 [1.3962; 3.1799]	3.55	<0.01	F	6.25	0.18	36.0	2.4697	0.0901
TT vs AA	5	166	353	4.5788 [2.6606; 7.8797]	5.49	<0.01	F	1.64	0.80	0	0.8015	0.4814
TT vs AA + TA	5	263	587	2.5579 [1.6680; 3.9226]	4.31	<0.01	F	1.52	0.82	0	1.2684	0.2941
TT + TA vs AA	5	263	587	2.5599 [1.7424; 3.7611]	4.79	<0.01	F	6.94	0.14	42.4	1.3346	0.2743

^aRandom-effects model was used when the P for heterogeneity test < 0.05, otherwise the fixed-effect model was used; ^bP <  0.05 is considered statistically significant for Q statis­tics; ^cEgger‘s test to evaluate publication bias, P <  0.05 is consid­ered statistically significant; OR: Odds ratio; CI: confidence interval; K: The number of included studies; AA: aplastic anemia group; Co: control group; F: Fixed-effect model.