High expression of CD56 may be associated with favorable overall survival in intermediate-risk acute myeloid leukemia

Figures & data

Figure 1. Overall survival (OS) analysis of CD56 in intermediate-risk acute myeloid leukemia (IR-AML) in the GSE12417-GPL96 (A), the Cancer Genome Atlas (TCGA) (B) and GSE71014-GPL-10558 (C) datasets. The optimal cut-off values for CD56, and survival time distribution (middle panel) and Kaplan-Meier curves (right panel) based on the expression levels of CD56 are shown. CI, confidence interval.

Figure 2. The restricted mean survival time (RMST) of IR-AML patients according to the expression levels of CD56 in the GSE12417-GPL96 (A), TCGA (B), and GSE71014-GPL-10558 (C) datasets.

Table 1. Clinical information of patients with intermediate-risk acute myeloid leukemia.

Variables	Coelho-Silva et al.	GSE12417-GPL96	TCGA	GSE71014-GPL10558
Number	64	161	92	104
Age, y, median (range)	49 (18, 84)	58 (17, 83)	57 (21, 88)	-
FAB classification, n (%) *
M0	-	5 (3.1)	6 (6.5)	-
M1	-	44 (27.3)	25 (27.2)	-
M2	-	45 (28.0)	20 (21.7)	-
M3	-	0 (0)	1 (1.1)	-
M4	-	41 (25.5)	23 (25)	-
M5	-	19 (11.8)	14 (15.2)	-
M6	-	6 (3.7)	1 (1.1)	-
M7	-	0 (0)	1 (1.1)	-
unknown	-	1 (0.6)	1 (1.1)	-
Sample source	Bone marrow	Bone marrow	Bone marrow	Bone marrow
Treatment	Chemotherapy or follow-up ASCT or HSCT	Chemotherapy or follow-up ASCT	Chemotherapy or follow-up HSCT	Chemotherapy or follow-up HSCT
Detection method	flow cytometry	microarray	microarray	microarray
Follow up, d, median (range)	208 (-)	280 (1, 1176)	395 (28, 2681)	440 (3, 5556)
Status (alive / dead), n	-	59 / 102	31 / 61	68 / 36

* Due to rounding, not all percentages total 100%; ASCT, autologous stem cell transplantation; FAB, French–American–British classification systems; HSCT, allogeneic hematopoietic stem cell transplantation; TCGA, the cancer genome atlas.

Data availability statement

The datasets used and analyzed during this study are available from UCSC XENA platform (https://xenabrowser.net/datapages/) and GEO database (https://www.ncbi.nlm.nih.gov/geo/). The data that support the findings of this study are available from the corresponding author upon reasonable request.