Polymorphisms in the GCK gene increase the risk of clopidogrel resistance in stable coronary artery disease (SCAD) patients

Figures & data

Table 1. Comparison of characteristics between CR and NCR patients.

Index	Non-CR (n = 114)	CR (n = 96)	χ^2/z/t	P value
Age (years)	59 (51.2, 68.15)	67 (55.1, 72.95)	11.098	0.002
BMI (kg/m^2)	23.71 (20.62, 26.91)	23.98 (22.87, 25.26)	0.275	0.623
Total cholesterol (mg/dL)	4.39 (3.79, 5.68)	4.18 (3.74, 4.98)	0.767	0.367
Triglyceride (mg/dL)	1.34 (1.07, 2.23)	1.42 (0.93, 1.63)	2.259	0.144
HDL (mg/dL)	0.93 (0.78, 1.11)	0.99 (0.76, 1.21)	1.337	0.256
LDL (mg/dL)	2.56 (2.03, 3.51)	2.36 (1.95, 2.99)	1.248	0.257
Fasting blood-glucose	5.16 (4.67, 5.81)	5.37 (4.61, 7.16)	1.797	0.185
ALT (umol/L)	26.1 (16.6, 47.2)	23.5 (15.1, 42.4)	0.956	0.337
AST (umol/L)	25.2 (18.7, 135.2)	26.1 (18.2, 77.5)	0.179	0.675
Albumin (g/L)	40.3 (36.7, 43.1)	38.2 (36.1, 40.1)	12.867	<0.001
BUN (mmol/L)	5.21 (4.06, 6.75)	5.52 (4.85, 6.64)	1.359	0.250
Cr (μmol/L)	67.3 (63.2, 73.8)	76.5 (64.5, 85.6)	10.499	0.012
UA (ummol/L)	278 (152, 333)	333 (279, 409)	19.812	0.003
hsCRP (mg/dL)	1.84 (0.99, 8.47)	3.32 (0.61, 10.31)	0.204	0.878
HbA1c (%)	5.9 (5.6, 6.3)	5.7 (5.5, 6.7)	0.079	0.782
Gender (male)	27	69	1.074	0.300
Hypertension, n	27	69	1.463	0.226
Diabetes mellitus, n	78	18	0.754	0.385
Concomitant medication
Pantoprazole	114	96	—	—
Statin	114	96	—	—

Table 2. Comparison of the SNPs in rs4607517 and rs6975024 between CR and NCR patients.

SNP ID	Non-CR (n = 114)	CR (n = 96)	χ^2	P value
rs4607517
GG	56	67	9.312	0.010
AG	48	23
AA	10	6
rs6975024
CC	10	10	11.226	0.004
TC	59	28
TT	45	58

Table 3. Comparison of the different SNP models between CR and NCR patients.

	Non-CR	CR	P value		Non-CR	CR	P value
rs4607517				rs6975024
GG vs.	56	67	0.003	CC vs.	10	10	0.505
AG + AA	58	29		TC + TT	104	76
GG + AG vs.	104	90	0.492	CC + TC vs.	69	38	0.003
AA	10	6		TT	45	58
GG vs.	56	67	0.201	CC vs.	10	10	0.604
AA	10	6		TT	45	58
G vs.	160	157	0.006	C vs.	79	48	0.032
A	68	35		T	149	144

Note: Bold values represent that the results were of statistical significance.

Table 4. Comparison of GCK rs4607517 in the subgroups between CR and NCR patients.

Index		Genotype	Non-CR	CR	X^2	P value
Age	<60	GG	27	20	6.435	0.040
		AG	24	4
		AA	6	3
	≥60	GG	29	47	3.880	0.144
		AG	24	19
		AA	4	3
Albumin	<40	GG	31	54	8.091	0.017
		AG	14	14
		AA	10	3
	≥40	GG	25	13	9.044	0.011
		AG	34	9
		AA	0	3
CREA	<97	GG	53	57	5.566	0.062
		AG	38	19
		AA	10	6
	≥97	GG	3	10	6.312	0.012
		AG	10	4
		AA	0	0
UA	<428	GG	48	63	13.996	0.001
		AG	45	20
		AA	10	3
	≥428	GG	8	4	4.295	0.117
		AG	3	3
		AA	0	3

Table 5. Comparison of GCK rs6975024 in the subgroups between CR and NCR patients.

Index		Genotype	Non-CR	CR	X^2	P value
Age	<60	GG	4	3	4.868b	0.088
		AG	27	6
		AA	26	18
	≥60	GG	6	7	8.336c	0.015
		AG	32	22
		AA	19	40
Albumin	<40	GG	8	7	6.062b	0.048
		AG	20	14
		AA	27	50
	≥40	GG	2	3	2.484c	0.289
		AG	39	14
		AA	18	8
CREA	<97	GG	10	10	5.093b	0.078
		AG	46	24
		AA	45	48
	≥97	GG	0	0	14.748c	0.000
		AG	13	4
		AA	0	10
UA	<428	GG	10	7	14.155b	0.001
		AG	56	25
		AA	37	54
	≥428	GG	0	3	4.295c	0.117
		AG	3	3
		AA	8	4

Table 6. Multiple logistic regression analysis of nongenetic and genetic factors.

Index	B	Std. Error	Wald	P value	Exp (B) (95% C.I)
rs4607517 GG + AG/AA	.035	.793	.002	0.965	1.036 (0.219,4.901)
rs6975024 CC + TC/TT	−.772	.345	5.001	0.025	0.462 (0.235,0.909)
Age	.014	.018	.620	0.431	1.014 (0.980,1.050)
Albumin	−.145	.051	7.984	0.005	0.865 (0.782,0.956)
CREA	.015	.011	1.875	0.171	1.016 (0.993,1.038)
UA	.007	.002	15.891	0.000	1.007 (1.004,1.001)
Constant	2.786	2.632	1.121	0.290	16.213

Note: Bold values represent that the results were of statistical significance.