Neutrophil CD64: a potential biomarker for the diagnosis of infection in patients with haematological malignancies

Figures & data

Table 1. Patients’ baseline characteristics.

Disease (n)	Case(n)	Sex		Age (years old)	Type of infection (n)
		Male	Female		Pneumonia	Sepsis	Skin-soft tissue infection	Virus infection	Urinary infection
AL	39	24	15	55(15–82)	35	2	2	–	–
CL	4	4	0	72(28–94)	3	–	–	–	1
MDS	13	6	7	73(60–84)	12	1	–	–	–
MM	8	2	6	66.5(63–78)	8	–	–	–	–
Lymphoma	12	4	8	66(26–81)	10	1	–	1	–

AL: acute leukaemia; CL: chronic leukaemia; MM: multiple myeloma; MDS: myelodysplastic syndrome; CI: confidence interval.

Table 2. Index in patients’infection and infection-control status.

	Case (n)	WBC (*10^9 /L)	NEUT (*10^9 /L)	CD64	PCT (mg/L)
Infection status	76	3.77 (0.14–53.16)	1.61 (0–66.40)	4.37 (0.98–58.49)	0.21 (0.01–70.56)
Infection-control status	76	4.0 (0.12–32.22)	1.79 (0.01–25.55)	1.11 (0.15–13.58)	0.15 (0.01–8.84)
p value	–	0.073	0.163	<0.001	0.001

Table 3. Cut-off value of infection index.

Biomarker	Cut-off value	Sensitivity(%)	Specificity(%)
WBC(*10^9 /L)	10.80	31.0%	90.5%
NEUT(*10^9 /L)	2.30	45.2%	69.0%
Neutrophil CD64	2.72	76.2%	71.4%
PCT(mg/L)	0.2	50.0%	64.3%

Figure 1. ROC curves for WBC, NEUT, neutrophil CD64 and PCT in the whole group.

Table 4. Index in neutropenia patients’infection and infection-control status.

	Case (n)	WBC (*10^9 /L)	NEUT (*10^9 /L)	CD64	PCT (mg/L)
Infection status	44	2.14 (0.14–21.30)	0.85 (0–1.87)	6.25(1.58–58.49)	0.25(0.02–70.56)
Infection-control status	44	2.86 (0.23–19.15)	0.83 (0.01–5.64)	1.32 (0.23–13.68)	0.19(0.01–3.76)
p value	–	0.066	0.051	<0.001	0.003

Table 5. Cut-off value of infection index in neutropenia group.

Biomarker	Cut-off value	Sensitivity(%)	Specificity(%)
WBC(*10^9 /L)	1.73	68.0%	57.9%
NEUT(*10^9 /L)	0.52	68.4%	63.2%
Neutrophil CD64	3.60	73.7%	68.4%
PCT(mg/L)	0.19	63.2%	52.6%

Figure 2. ROC curves for WBC, NEUT, neutrophil CD64 and PCT in neutropenia group.