Association between TNF-α gene polymorphisms and susceptibility of myelodysplastic syndromes: a meta-analysis

Figures & data

Figure 1. Flow diagram of study selection.

Table 1. Main characteristic of studies in the meta-analysis.

First author	Year	Country	Ethnicity	Genotyping methods	Source of controls	Polymorphism	HWE	Case/control	Study design	NOS
Balog A	2005	Hungary	Caucasian	PCR-RFLP	PB	G308A	0.63	50/74	Case-control	8
Gyulai Z	2005	Hungary	Caucasian	PCR-RFLP	PB	G308A	0.63	55/74	Case-control	8
Kadar K	2005	Hungary	Caucasian	PCR-RFLP	PB	G308A G238A	0.71 0.70	69/125	Case-control	7
Powers MP	2007	America	Caucasian	PCR-SSP	PB	G308A G238A	0.01 0.80	18/376 18/102	Case-control	6
Parnes A	2010	America	Caucasian	PCR-RFLP	PB	G308A G238A	0.06 0	328/150	Cohort	5
Belli CB	2011	Argentine	Caucasian	PCR-RFLP	PB	G308A	0.96	101/92	Case-control	8
Xu JQ	2013	China	Asian	TaqMan	PB	G308A G238A	0.80 0.76	341/365	Case-control	8
Bestach Y	2017	Argentine	Caucasian	PCR-RFLP	HB	G308A	0.90	152/131	Case-control	8

Abbreviations: PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; PCR-SSP: polymerase chain reaction-sequence specific primer; HB: hospital-based; PB: population-based; HWE: Hardy-Weinberg equilibrium; NOS: Newcastle-Ottawa quality assessment scale.

Figure 2. Forest plots of pooled ORs and 95% CI for evaluating the association between TNF-α G308A polymorphism and MDS susceptibility in six different genetic models: (A) allelic (G versus A), (B) heterozygous (GG versus GA), (C) over-dominant (GG + AA versus GA), (D) recessive (GG versus GA + AA), (E) homozygous (GG versus AA), (F) dominant (GG + GA versus AA).

Figure 3. Forest plots of pooled ORs and 95% CI for evaluating the association between TNF-α G308A polymorphism and MDS susceptibility according to different ethnicities in four different genetic models: (A) allelic (G versus A), (B) heterozygous (GG versus GA), (C) over-dominant (GG + AA versus GA), (D) recessive (GG versus GA + AA).

Figure 4. Forest plots of pooled ORs and 95% CI for evaluating the association between TNF-α G238A polymorphism and MDS susceptibility in six different genetic models: (A) allelic (G versus A), (B) heterozygous (GG versus GA), (C) over-dominant (GG + AA versus GA), (D) recessive (GG versus GA + AA), (E) homozygous (GG versus AA), (F) dominant (GG + GA versus AA).