Sublingual methylcobalamin treatment is as effective as intramuscular and peroral cyanocobalamin in children age 0–3 years

Figures & data

Figure 1. Participants’ vitamin B12 values before and after oral cyanocobalamin, intramuscular cyanocobalamin, and sublingual methylcobalamin vitamin B12 treatments. Group 1: Oral cyanocobalamin therapy group, Group 2: Sublingual Methylcobalamin therapy group, Group 3: Intramuscular cyanocobalamin therapy group.

Table 1. Vitamin B12, Hemoglobin And Platelet Levels Before And After Treatment Among Groups.

Vitamin B12 Treatment Group	Serum levels	Pre-treatment mean ± standart deviation (min-max)	Post-treatment mean ± standart deviation (min-max)	P value
Group 1	vit B12 (ng/L)	201.1 ± 63.2	449.2.2 ± 285	<0.001*
		(121-299)	(201-1859)
	Hb (g/dL)	11.6 ± 1.2	12.0 ± 1.4	0.007*
		(6.5-13.7)	(1.8-13.9)
	Plt (bin/µL)	381.1 ± 109.1	354.2 ± 95.1	0.114
		(201-957)	(123-744)
Group 2	vit B12 (ng/L)	187 ± 49.2	427.1 ± 172.1	<0.001*
		(109-250)	(286-1081)
	Hb (g/dL)	11.3 ± 2.1	11.5 ± 1.2	0.150
		(10.2-16.9)	(1.5-14.5)
	Plt (bin/µL)	374.1 ± 109.1	377.1 ± 95.1	0.428
		(161-724)	(156-588)
Group 3	vit B12 (ng/L)	176.1 ± 64.2	526.1 ± 284.1	<0.001*
		(83-659)	(224-1525)
	Hb (g/dL)	12.1 ± 1.2	12.1 ± 1.2	0.092
		(5.3-13.5)	(8.5-14.1)
	Plt (bin/µL)	385.1 ± 109.1	359.1 ± 92.5	0.668
		(207-607)	(226-575)

*p < 0.05: statistically significant

Group 1: Oral cyanocobalamin therapy group,

Group 2: Sublingual Methylcobalamin therapy group, Group 3: Intramuscular cyanocobalamin therapy group. Vit B12: Vitamin B12, Hb: hemoglobin, Plt: Platelet.