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Research Article

Bridging to transplant and post-transplant maintenance therapy with FLT3 inhibitors in patients with relapsed or refractory FLT3 mutated acute myeloid leukemia

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Article: 2220518 | Received 31 Jan 2023, Accepted 29 May 2023, Published online: 05 Jun 2023

Figures & data

Figure 1. Clinical course of the 10 study patients before and after hematopoietic stem cell transplantation. Gilteritinib and quizartinib doses (mg/body) are indicated numerically. AEs were grade 3 or higher and were indicated by letters such as ‘SOS/VOD’.

(red): relapse;
(red): diagnosis;
: CR indicates complete remission;
: NR, non-remission;
(yellow): HCT, allogeneic hematopoietic cell transplantation;
(black): chemo therapy;
(blue): gilteritinib; fx8(green): quizartinib;
(orange): AE, adverse event;
: death, PCP, pneumocystis pneumonia; SOS/VOD, sinusoidal obstructive syndrome/veno-occlusive disease.

Figure 1. Clinical course of the 10 study patients before and after hematopoietic stem cell transplantation. Gilteritinib and quizartinib doses (mg/body) are indicated numerically. AEs were grade 3 or higher and were indicated by letters such as ‘SOS/VOD’. Display full size(red): relapse; Display full size(red): diagnosis; Display full size: CR indicates complete remission; Display full size: NR, non-remission; Display full size(yellow): HCT, allogeneic hematopoietic cell transplantation; Display full size(black): chemo therapy; Display full size(blue): gilteritinib; fx8(green): quizartinib; Display full size(orange): AE, adverse event; Display full size: death, PCP, pneumocystis pneumonia; SOS/VOD, sinusoidal obstructive syndrome/veno-occlusive disease.

Table 1. Patient characteristics from diagnosis to transplantation.

Table 2. Profile of maintenance therapy.

Figure 2. Outcomes of the cohort: (a) overall survival, and (b) disease-free survival starting from transplantation. OS indicates overall survival; DFS, disease-free survival.

Figure 2. Outcomes of the cohort: (a) overall survival, and (b) disease-free survival starting from transplantation. OS indicates overall survival; DFS, disease-free survival.

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.