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Journal of Endocrinology, Metabolism and Diabetes of South Africa Volume 24, 2019 - Issue 2
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Clinical Review

Lifestyle modification in the management of insulin resistance states in overweight/obesity: the role of exercise training

Tshidi ThaaneDiscipline of Biokinetics, Exercise and Leisure Sciences, University of KwaZulu-Natal, Durban, South Africa;Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2420-2905
ORCID Icon,
Ayesha A MotalaDepartment of Diabetes and Endocrinology, University of KwaZulu-Natal, Durban, South Africa;
&
Andrew J MckuneDiscipline of Biokinetics, Exercise and Leisure Sciences, University of KwaZulu-Natal, Durban, South Africa;;University of Canberra Research Institute for Sport and Exercise Science, University of Canberra, Canberra, Australia;;Collaborative Research in Bioactives and Biomarkers (CRIBB) Group, University of Canberra, Canberra, AustraliaORCID Iconhttp://orcid.org/0000-0002-5479-1544
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Pages 65-69 | Received 12 Jan 2019, Accepted 12 Apr 2019, Published online: 22 May 2019

Figures & data

Figure 1. Schematic representation of the insulin signalling pathway showing defects in the signalling cascade in insulin resistance (Adapted from Fröjdö et al.).Citation13 IRS: insulin receptor substrate; Grb2: growth factor receptor-bound protein 2; SOS: Son of Sevenless; Erk/12: extracellular signal-regulated kinases 1/2; PIP3: phosphatidylinositol 3 kinase; PDK1: phosphoinositide-dependent kinase-1; PKC: protein kinase C; Akt: serine-threonine protein kinase; GSK3: glycogen synthase kinase 3; UDP: uridine diphosphate; GLUT4-glucose transported 4.

Figure 1. Schematic representation of the insulin signalling pathway showing defects in the signalling cascade in insulin resistance (Adapted from Fröjdö et al.).Citation13 IRS: insulin receptor substrate; Grb2: growth factor receptor-bound protein 2; SOS: Son of Sevenless; Erk/12: extracellular signal-regulated kinases 1/2; PIP3: phosphatidylinositol 3 kinase; PDK1: phosphoinositide-dependent kinase-1; PKC: protein kinase C; Akt: serine-threonine protein kinase; GSK3: glycogen synthase kinase 3; UDP: uridine diphosphate; GLUT4-glucose transported 4.

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