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Global Health Action Volume 14, 2021 - Issue 1
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Original Article

Effect of antiretroviral therapy initiation time and baseline CD4+ cell counts on AIDS-related mortality among former plasma donors in China: a 21-year retrospective cohort study

Yongli Yanga Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaORCID Iconhttps://orcid.org/0000-0002-2797-0686View further author information
ORCID Icon,
Yang Lia Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaORCID Iconhttps://orcid.org/0000-0003-1784-6638View further author information
ORCID Icon,
Xuening Zhanga Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Weiping Zhanga Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Yanmin Mab Institute of STD/AIDS Prevention and Control, Henan Provincial Center for Diseases Prevention and Control, Zhengzhou, ChinaView further author information
,
Xiaocan Jiaa Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China;c Zhengzhou University Library, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Theodore Gondwea Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaView further author information
,
Yuping Wanga Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaView further author information
&
Xuezhong Shia Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1694-1011View further author information
ORCID Icon show all
Article: 1963527 | Received 10 Jan 2021, Accepted 29 Jul 2021, Published online: 01 Oct 2021

Figures & data

Table 1. Characteristics of HIV/AIDS patients [n(%)]

Figure 1. Cumulative incidence curves of AIDS-related mortality in Henan province: 1995–2016 (N = 11,905). ((a) Cumulative incidence curves of AIDS-related mortality; (b) Cumulative incidence curves of AIDS-related mortality for HIV patients and AIDS patients; (c) Cumulative incidence curves of AIDS-related mortality for patients with initiation of ART and ART-naive; (d) Cumulative incidence curves of AIDS-related mortality for patients with different CD4+ cell counts)

ART: antiretroviral therapy; HIV: human immunodeficiency virus; AIDS: acquired immune deficiency syndrome.
Figure 1. Cumulative incidence curves of AIDS-related mortality in Henan province: 1995–2016 (N = 11,905). ((a) Cumulative incidence curves of AIDS-related mortality; (b) Cumulative incidence curves of AIDS-related mortality for HIV patients and AIDS patients; (c) Cumulative incidence curves of AIDS-related mortality for patients with initiation of ART and ART-naive; (d) Cumulative incidence curves of AIDS-related mortality for patients with different CD4+ cell counts)

Table 2. Prognostic factors of entire study cohort and each subgroup based on baseline CD4+ cell counts [sHR (95% CI)]

Figure 2. AIDS-related mortality stratified by time of ART initiation and baseline CD4+ cell counts. (Competing risk model adjusted for gender, age, educational level, marital status, occupation, transmission, and disease stage at diagnosis)

ART: antiretroviral therapy; AIDS: acquired immune deficiency syndrome.
Figure 2. AIDS-related mortality stratified by time of ART initiation and baseline CD4+ cell counts. (Competing risk model adjusted for gender, age, educational level, marital status, occupation, transmission, and disease stage at diagnosis)

Figure 3. Model performance of entire study cohort based on time-dependent ROC. ((a) time-dependent ROC curve; (b) AUC(t) values and 95% CI)

Time-dependent ROC: time-dependent receiver operating characteristic curve; AUC(t): the area under time-dependent receiver operating characteristic curve; CI: confidence interval.
Figure 3. Model performance of entire study cohort based on time-dependent ROC. ((a) time-dependent ROC curve; (b) AUC(t) values and 95% CI)

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