Synthesis and anticancer evaluation of imidazolidine derivatives: study the reaction of imidazolidineiminothione derivatives with amino acids methyl ester

Figures & data

Figure 1. Some commercial drugs and biologically active compounds with imidazole moiety.

Scheme 1. Synthesis of imidazolidineiminothione derivatives 1

Scheme 2. Reaction of imidazolidineiminothione1a with (S)-tryptophan methyl ester

Scheme 3. Reaction of imidazolidineiminothiones 1 with 4-hydroxy-R-phenylglycine methyl Ester 4

Scheme 4. Reaction of imidazolidineiminothiones with tert-butyl(4-aminophenyl) carbamate

Table 1. Cytotoxic activity of the synthesized imidazole derivatives against the cancerous cell lines.

	IC50 (μM/mL)
Compound No.	HCT-116	HEPG-2	MCF-7
3	20.89	21.18	23.11
5a	4.91	5.02	4.78
6b	6.98	7.12	6.88
6c	24.48	22.31	23.89
8a	11.36	10.12	9.53
Doxorubicin	8.29	7.46	4.56

Figure 2. Comparison between the anticancer activity of our synthesized compounds and Doxorubicin.