Estimating chiral selector potential of micelle-based mobile phases through the analysis of some enantiomeric mixtures

Figures & data

Table 1. Physico-chemical properties of the studied drugs.

Figure 1. Chiral separation in a chiral medium (Method A) using the described MLC for the separation of racemic mixture of: (a is enantiomer #1, b is enantiomer # 2)$\begin{array}{ll}\begin{array}{l}\mathrm{A}:200.0\mu \mathrm{g}/\mathrm{mL}\mathrm{PHR}\\ \mathrm{B}:200.0\mu \mathrm{g}/\mathrm{mL}\mathrm{MBV}\\ \mathrm{C}:200.0\mu \mathrm{g}/\mathrm{mL}\mathrm{CTZ}\end{array}\}& \boxed{{\displaystyle \text{Anionic based MLC (SDS)}}}\\ \mathrm{D}:200.0\mu \mathrm{g}/\mathrm{mL}\mathrm{CTZ}\}& \boxed{{\displaystyle \text{Cationic based MLC (CTM)}}}\end{array}$.

Figure 2. Chiral separation in chiral medium (Method B) using the described HMLC for the separation of racemic mixture of 200.0 µg/mL CTZ on cellulose 1 column: (a is enantiomer #1, b is enantiomer # 2).

Scheme 1. Postulation of chiral separation mechanism of PHR in achiral medium using the SDS-based mobile phase at pH 6.

Scheme 2. Postulation of chiral separation mechanism of CTZ in achiral medium using the CTM-based mobile phase at pH 4.

Scheme 3. Postulation of chiral separation mechanism of CTZ in a chiral medium using the HMLC mobile phase and cellulose 1 chiral column.