Figures & data
Scheme 1. Synthesis of phenylvinyl-bridged dyes comprising hydroxylic substituents.
Scheme 2. Synthesis of phenyl-bridged dye comprising 2° amine group.
Scheme 3. Synthesis of phenyl and phenylvinyl-bearing DCDHF dyes with a HTCX group.
Scheme 4. Synthesis of phenyl and phenylvinyl-bearing DCDHF dyes with a LSHA group.
Figure 1. Emission spectra of DCDHF fluorophores.
Table 1. Photophysical parameters of DCDHF fluorophores.
Table 2. MIC results for the synthesized HTCX /LSHA-based hybrids.
Table 3. Binding energy (ΔG) and the percentage DHFR inhibition of the synthesized compounds against DHFR.
Table 4. In silico docking results of the prepared HTCX / LSHA-based fluorophores.
Figure 2. Docking images of HTCX -based hybrid 6 with 1LNZ.
Figure 3. Docking images of HTCX -based hybrid DCDHF-7 with 1LNZ.
Figure 4. Docking images of HTCX -based hybrid DCDHF-8 with 1LNZ.
Figure 5. Docking images of LSHA-based hybrid DCDHF-15 with 1LNZ.
Figure 6. Docking images of LSHA-based hybrid DCDHF-16 with 1LNZ.
Figure 7. Docking images of Ampicillin with 1LNZ.
Figure 8. Docking images of HTCX -based hybrid 6 with 1AD4.
Figure 9. Docking images of HTCX -based hybrid 7 with 1AD4.
Figure 10. Docking images of HTCX -based hybrid 8 with 1AD4.
Figure 11. Docking images of HTCX -based hybrid 15 with 1AD4.
Figure 12. Docking images of HTCX -based hybrid 16 with 1AD4.
Figure 13. Docking images of HTCX -based hybrid Trimethoprim with 1AD4.
Table 5. In silico docking results of the prepared HTCX / LSHA-based against PDB: 1AD4.