Gene detection of VDR BsmI locus and its approteins, genes and growthplication in rational drug use in patients with osteoporosis

Figures & data

Table 1. Frequency distribution of vitamin D receptor genotypes in male and female populations in Guangdong [n (%)].

Parameters			VDR Genotype				Frequency
Sex	Sum	bb	Bb	BB	p-value^2	p-value	b	B	p-value^2	p-value
M	136	119 (88.15)	16 (11.85)	1 (0.74)	4.578	0.101	127 (94.07)	9 (6.67)	3.698	0.157
F	214	199 (93.46)	14 (6.54)	0 (0.0)			207 (96.73)	7 (3.27)

F: Female; M: Male; VDR: Vitamin D receptor.

Table 2. Comparison of vitamin D receptor genotype frequencies in this region and the country and other regions (n [%]).

Region	Sum (n)	VDR Genotype					Frequency
		bb	Bb	BB	χ^2	p-value	b	B	χ^2	p-value
Foshan (study)	350	319 (91.66)	30 (8.72)	1 (0.21)			324 (95.43)	16 (4.57)
Guangzhou	368	325 (88.3)	42 (11.4)	1 (0.3)	0.434	0.804	692 (94.0)	44 (6.0)	0.204	0.651
Xinjiang	336	290 (86.3)	36 (10.7)	10 (3)	2.787	0.248	616 (91.7)	56 (8.3)	1.155	0.282
Harbin	98	82 (83.7)	16 (16.3)	0	2.866	0.238	90 (91.8)	8 (8.2)	1.102	0.293
Fuzhou	150	134 (89.4)	11 (7.3)	5 (3.3)	2.873	0.237	139.5|(93)	10.5 (7)	0.542	0.461
Shanghai	611	511 (83.6)	100 (16.4)	0	2.927	0.231	561 (91.8)	50 (8.2)	1.102	0.293

VDR: Vitamin D receptor.

Table 3. Comparison of allele frequencies of different populations with the Thousand Genomes Database (n [%]).

	Allele	Guangdong	East Asia	South Asia	America(a)	Europe(a)	Africa(a)
Point		n = 350	n = 1008	n = 978	n = 694	n = 1006	n = 1322
VDR	b	95.42	93.6	51.5	74.4	59.6	72.8
	B	4.57	6.4	48.5	25.6	40.4	27.2

Note: a compared with Guangdong, p < 0.05.

VDR: Vitamin D receptor.

Table 4. Comparison of bone mineral density T scores before and after treatment.

Bone Region	Number of cases	BMD before treatment	BMD after treatment
Lumbar vertebrae 2–4 (x ± s)	18	-3.98 ± 1.03	-3.87 ± 1.16

BMD: Bone mineral density.

Data availability statement

The simulation experiment data used to support the findings of this study are available from the corresponding author upon request.