Abstract
Highly diastereoselective 1,3-dipolar cycloaddition of in situ generated C,N-diaryl nitrilimines to (1R)-thiocamphor leads to chiral spiro-1,3,4-thiadiazolocamphane derivatives in good yields. The structures and stereochemistries of the new cycloadducts were fully established by spectroscopic methods including X-ray diffraction data. The diastereoselectivity observed in this reaction was explained by means of a brief theoretical study.
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