A convenient solvent-free and one-pot synthesis of 4-hydroxythiazolidine-2-thiones

Abstract

A highly efficient solvent-free and simple one-pot approach for the synthesis of 4-hydroxythiazolidine-2-thione is described. The reaction of primary amines and carbon disulfide in the presence of 2-chloroacetaldehyde afforded the title compounds in high yields.

GRAPHICAL ABSTRACT

Keywords:

• 2-chloroacetaldehyde
• primary amines
• dithiocarbamate
• carbon disulfide

Acknowledgements

We are grateful to Dr Farzad Nikpour for his assistance.

Supplemental data

for this article can be accessed at http://dx.doi.org/10.1080/17415993.2014.907407.