Abstract
This review describes the reactions of o-aminothiophenol and its derivatives as building blocks for the synthesis of polyfunctionalized benzothiazoles with pharmacological interest. Annelated benzothiazoles were prepared by a cyclocondensation reaction of o-aminothiophenol and its derivatives with carbonyl and other functionalities. In the case of carbonyl functions, this reaction takes place by a nucleophilic addition, followed by cyclization concomitant with the elimination of water. The objective of this survey is to provide a comprehensive account of the synthesis of various benzothiazole systems and their potential to develop better chemotherapeutic agents.
GRAPHICAL ABSTRACT
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Acknowledgements
The author thanks Dr S.R. Ramadas, Retd. Professor of IIT-Chennai, India and Professor Edward Clennan, the Editor in chief of the Journal of Sulfur Chemistry for the technical discussion and constant encouragement.
Notes
† This article is dedicated to my beloved research guide Dr S. R. Ramadas, Retd. Professor of Chemistry, IIT-Chennai who left for his heavenly abode on 17 July 2013.