Silica gel-promoted new one-pot procedure for the synthesis of 1,3-oxathiolan-5-one

ABSTRACT

A highly selective two-component silica gel-promoted synthesis of 1,3-oxathiolan-5-one derivatives in N,N-Dimethylformamide (DMF) is presented. The reaction was carried out using aromatic aldehyde and mercaptoacetic acid in the presence of silica gel in DMF with heating. The reactions were worked up by separating the silica gel and recovering the solid product after adding water in excellent yields without any chromatographic purification. Structures of the compounds were satisfactorily confirmed by ¹H NMR and LCMS spectral analysis.

GRAPHICAL ABSTRACT

KEYWORDS:

• 1,3-oxathiolan-5-one
• silica gel
• one-pot synthesis
• aldehyde
• mercaptoacetic acid

Acknowledgements

We are thankful to the Head, Department of Chemistry, for his continuous support and guidance throughout the work.

Disclosure statement

No potential conflict of interest was reported by the authors.