A green and efficient synthesis of 2-thioxoquinazolinone derivatives in water using potassium thiocyanate

ABSTRACT

Green chemistry is one of the most important routes for the synthesis of heterocyclic compounds. In this regard, the synthesis of 2-thioxoquinazolinone derivatives was achieved by condensation of versatile materials including isatoic anhydride, amine and potassium thiocyanate in the green medium of water. This convenient and efficient method affords the desired products with good to excellent yields.

GRAPHICAL ABSTRACT

KEYWORDS:

• Thioxoquinazolinone
• green chemistry
• water
• isatoic anhydride
• potassium thiocyanate

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by grants from PNU, INSF and Tehran University of Medical Sciences as research project [Grant No: 33150-33-03-95].